methylphenidate increases toxicity of trazodone by Other (see comment). Monitor BP. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. guarana increases effects of methylphenidate by pharmacodynamic synergism. This drug is available at a higher level co-pay. perphenazine, methylphenidate. Use Caution/Monitor. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. Monitor BP. Monitor BP. Ritalin LA Metadate CD Concerta . thioridazine, methylphenidate. only. Mechanism: pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. only. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. ziprasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Applies only to oral form of both agents. Mechanism: unknown. Interaction more likely in certain predisposed pts. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. dobutamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Either increases effects of the other by serotonin levels. Either increases toxicity of the other by Other (see comment). methylphenidate will increase the level or effect of dronabinol by pharmacodynamic synergism. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Other (see comment). Methylphenidate may diminish antihypertensive effects. Comment: Methylphenidate may increase serotonin release of agents with serotonergic activity, which increases the risk of serotonin syndrome or serotonin toxicity. Monitor BP. Avoid or Use Alternate Drug. Contraindicated. sufentanil SL, methylphenidate. Use Caution/Monitor. Compare formulary status to other drugs in the same class. Monitor Closely (1)levalbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contraindicated. The recommended dose of CONCERTA for patients who are currently taking methylphenidate twice daily or three times daily at doses of 10 to 60 mg/day is provided in Table 2. Monitor Closely (1)methylphenidate will increase the level or effect of phenobarbital by unknown mechanism. Risk of acute hypertensive episode. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. amitriptyline, methylphenidate. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. lofepramine, methylphenidate. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Additive vasospasm; risk of hypertension. Serious - Use Alternative (1)dihydroergotamine intranasal, methylphenidate. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. methylphenidate will decrease the level or effect of fosinopril by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. terbutaline and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Other (see comment). Tranylcypromine. Mechanism: pharmacodynamic synergism. Monitor Closely (1)albuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Methylphenidate may diminish antihypertensive effects. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Modify Therapy/Monitor Closely. Monitor BP. Comment: Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. amantadine, methylphenidate. Minor (1)amantadine, methylphenidate. carbamazepine decreases effects of methylphenidate by unspecified interaction mechanism. Applies only to oral form of both agents. Risk of V tach, HTN. Use Caution/Monitor. Use Caution/Monitor. Monitor BP. Monitor Closely (1)risperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)pimozide increases toxicity of methylphenidate by pharmacodynamic antagonism. Interaction more likely in certain predisposed pts. Monitor BP. Use Caution/Monitor. Risk of acute hypertensive episode. Monitor BP. Monitor Closely (1)desipramine, methylphenidate. methylphenidate will decrease the level or effect of perindopril by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of phenoxybenzamine by pharmacodynamic antagonism. Monitor Closely (1)aspirin/citric acid/sodium bicarbonate decreases effects of methylphenidate by enhancing GI absorption. Either increases effects of the other by serotonin levels. Applies only to oral form of both agents. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. only. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Contraindicated. Use Caution/Monitor. Monitor BP. Monitor Closely (1)epinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contraindicated. Risk of acute hypertensive episode. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)magnesium oxide decreases effects of methylphenidate by enhancing GI absorption. restrictions. Contraindicated. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor BP. esketamine intranasal, methylphenidate. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor BP. Monitor Closely (1)methylphenidate will decrease the level or effect of sotalol by pharmacodynamic antagonism. Monitor Closely (1)metaproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use Caution/Monitor. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. Monitor BP. Contraindicated. Bupropion. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Methylphenidate may diminish antihypertensive effects. only.fluphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. formoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contraindicated (1)tranylcypromine increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Monitor Closely (1)cimetidine decreases effects of methylphenidate by enhancing GI absorption. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. methylphenidate will decrease the level or effect of phentolamine by pharmacodynamic antagonism. Use Caution/Monitor. Risk of acute hypertensive episode. Applies only to oral form of both agents. Monitor BP. Please confirm that you would like to log out of Medscape. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Methylphenidate may diminish antihypertensive effects. Monitor BP. Monitor Closely (1)pramipexole, methylphenidate. Modify Therapy/Monitor Closely. Monitor Closely (1)methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. Contraindicated. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Comment: Potential for additive CNS effects. Mechanism: pharmacodynamic synergism. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Potential for additive CNS stimulation. View explanations for tiers and Avoid or Use Alternate Drug. This drug is available at the lowest co-pay. procarbazine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Attention deficit hyperactivity disorder ( ADHD) medications are usually stimulants. Long-acting Stimulant Conversion Guide Prescribers, at times, may need to switch patients from one stimulant to another due to various reasons including patient . Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Either increases effects of the other by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Additive vasospasm; risk of hypertension. Conversion from methylphenidate to Concerta or Relexxii. Adding plans allows you to compare formulary status to other drugs in the same class. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)sufentanil SL, methylphenidate. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Applies only to extended release formulation. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. methylphenidate will decrease the level or effect of telmisartan by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (1)lisdexamfetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Monitor BP. Monitor BP. Contraindicated. Monitor Closely (1)methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. only. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Use Caution/Monitor. nortriptyline, methylphenidate. Monitor Closely (1)iloperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Applies only to oral form of both agents. Use Caution/Monitor. Applies only to oral form of both agents. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Dosing recommendations are based on current dose regimen and clinical judgment. Use Caution/Monitor. desmopressin increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)amitriptyline, methylphenidate. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Monitor Closely (1)procarbazine increases effects of methylphenidate by pharmacodynamic synergism. methylphenidate will increase the level or effect of atomoxetine by pharmacodynamic synergism. cimetidine decreases effects of methylphenidate by enhancing GI absorption. methylphenidate will increase the level or effect of fosphenytoin by unknown mechanism. Methylphenidate may diminish antihypertensive effects. Minor/Significance Unknown. Monitor Closely (1)chlorpromazine, methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of olmesartan by pharmacodynamic antagonism. Use Caution/Monitor. Mechanism: unknown. Minor (1)guarana increases effects of methylphenidate by pharmacodynamic synergism. Comment: Green tea may include caffeine. Risk of acute hypertensive episode. Monitor BP. Monitor Closely (1)imipramine, methylphenidate. Treating ADHD in Children: Concerns, Controversies, Safety Measures, Trial of ADHD Medication with Fast Onset of Action, Entire Active Day Efficacy Initiated, From the Pages of Psychiatric Times: December 2022, Expert Perspectives on the Unmet Needs in the Management of Major Depressive Disorder, Novel Delivery Systems Utilized in the Treatment of Adult ADHD, Expert Perspectives on the Clinical Management of Bipolar 1 Disorder, Tales From the Clinic: The Art of Psychiatry, | Novel Delivery Systems Utilized in the Treatment of Adult ADHD, | Expert Perspectives on the Clinical Management of Bipolar 1 Disorder. Avoid or Use Alternate Drug. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Interaction specifically associated with Ritalin LA. Other (see comment). Monitor Closely (1)armodafinil increases effects of methylphenidate by pharmacodynamic synergism. Mechanism: unknown. The above information is provided for general Minor/Significance Unknown. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. fenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. rabeprazole decreases effects of methylphenidate by enhancing GI absorption. Other (see comment). If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Risk of acute hypertensive episode. Applies only to oral form of both agents. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Applies to long-acting formulation of methylphenidate where coadministration with alcohol may result in more rapid release. Monitor Closely (1)ephedrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)epinephrine racemic and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contraindicated. Ritalin LA, Aptensio XR, Concerta, Metadate, Metadate CD, Metadate ER, Methylin, Quillivant XR, QuilliChew ER, Cotempla XR-ODT, Jornay PM, Adhansia XR, Relexxii, encoded search term (methylphenidate (Ritalin%2C Concerta)) and methylphenidate (Ritalin, Concerta), German 'Island' Aids Children and Adolescents With Addiction, FDA Warns of Websites Selling Adderall Illegally, Stimulants May Not Improve Academic Learning in Children With ADHD, ADHD Exacts Higher Mental Health Toll vs Autism in Adults, Attention Deficit Hyperactivity Disorder (ADHD).

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